| August 2024Aug 19 |  Serie A | Lecce 0–4 AtalantaRegular Season - 1 | L |
| Aug 24 | Serie A | Inter 2–0LecceRegular Season - 2 | L |
| Aug 31 | Serie A | Lecce1–0 CagliariRegular Season - 3 | W |
| September 2024Sep 15 | Serie A | Torino 0–0LecceRegular Season - 4 | D |
| Sep 21 | Serie A | Lecce2–2 ParmaRegular Season - 5 | D |
| Sep 27 | Serie A | AC Milan 3–0LecceRegular Season - 6 | L |
| October 2024Oct 05 | Serie A | Udinese 1–0LecceRegular Season - 7 | L |
| Oct 20 | Serie A | Lecce0–6 FiorentinaRegular Season - 8 | L |
| Oct 26 | Serie A | Napoli 1–0LecceRegular Season - 9 | L |
| Oct 29 | Serie A | Lecce1–0 Hellas VeronaRegular Season - 10 | W |
| November 2024Nov 02 | Serie A | Bologna 1–0LecceRegular Season - 11 | L |
| Nov 08 | Serie A | Lecce1–1 EmpoliRegular Season - 12 | D |
| Nov 25 | Serie A | Venezia 0–1LecceRegular Season - 13 | W |
| December 2024Dec 01 | Serie A | Lecce1–1 JuventusRegular Season - 14 | D |
| Dec 07 | Serie A | AS Roma 4–1LecceRegular Season - 15 | L |
| Dec 15 | Serie A | Lecce2–1 MonzaRegular Season - 16 | W |
| Dec 21 | Serie A | Lecce1–2 LazioRegular Season - 17 | L |
| Dec 30 | Serie A | Como 2–0LecceRegular Season - 18 | L |
| January 2025Jan 05 | Serie A | Lecce0–0 GenoaRegular Season - 19 | D |
| Jan 11 | Serie A | Empoli1–3LecceRegular Season - 20 | W |
| Jan 19 | Serie A | Cagliari4–1LecceRegular Season - 21 | L |
| Jan 26 | Serie A | Lecce0–4InterRegular Season - 22 | L |
| Jan 31 | Serie A | Parma1–3LecceRegular Season - 23 | W |
| February 2025Feb 09 | Serie A | Lecce0–0BolognaRegular Season - 24 | D |
| Feb 16 | Serie A | Monza0–0LecceRegular Season - 25 | D |
| Feb 21 | Serie A | Lecce0–1UdineseRegular Season - 26 | L |
| Feb 28 | Serie A | Fiorentina1–0LecceRegular Season - 27 | L |
| March 2025Mar 08 | Serie A | Lecce2–3AC MilanRegular Season - 28 | L |
| Mar 14 | Serie A | Genoa2–1LecceRegular Season - 29 | L |
| Mar 29 | Serie A | Lecce0–1AS RomaRegular Season - 30 | L |
| April 2025Apr 06 | Serie A | Lecce1–1VeneziaRegular Season - 31 | D |
| Apr 12 | Serie A | Juventus2–1LecceRegular Season - 32 | L |
| Apr 19 | Serie A | Lecce0–3ComoRegular Season - 33 | L |
| Apr 27 | Serie A | Atalanta1–1LecceRegular Season - 34 | D |
| May 2025May 03 | Serie A | Lecce0–1NapoliRegular Season - 35 | L |
| May 11 | Serie A | Hellas Verona1–1LecceRegular Season - 36 | D |
| May 18 | Serie A | Lecce1–0TorinoRegular Season - 37 | W |
| May 25 | Serie A | Lazio0–1LecceRegular Season - 38 | W |
