| August 2025Aug 23 |  Serie A | Genoa 0–0 LecceRegular Season - 1 | D |
| Aug 29 | Serie A | Lecce0–2 AC MilanRegular Season - 2 | L |
| September 2025Sep 14 | Serie A | Atalanta 4–1LecceRegular Season - 3 | L |
| Sep 19 | Serie A | Lecce1–2 CagliariRegular Season - 4 | L |
| Sep 28 | Serie A | Lecce2–2 BolognaRegular Season - 5 | D |
| October 2025Oct 04 | Serie A | Parma 0–1LecceRegular Season - 6 | W |
| Oct 18 | Serie A | Lecce0–0 SassuoloRegular Season - 7 | D |
| Oct 25 | Serie A | Udinese 3–2LecceRegular Season - 8 | L |
| Oct 28 | Serie A | Lecce0–1 NapoliRegular Season - 9 | L |
| November 2025Nov 02 | Serie A | Fiorentina 0–1LecceRegular Season - 10 | W |
| Nov 08 | Serie A | Lecce0–0 Hellas VeronaRegular Season - 11 | D |
| Nov 23 | Serie A | Lazio 2–0LecceRegular Season - 12 | L |
| Nov 30 | Serie A | Lecce2–1 TorinoRegular Season - 13 | W |
| December 2025Dec 07 | Serie A | Cremonese 2–0LecceRegular Season - 14 | L |
| Dec 12 | Serie A | Lecce1–0 PisaRegular Season - 15 | W |
| Dec 27 | Serie A | Lecce0–3 ComoRegular Season - 17 | L |
| January 2026Jan 03 | Serie A | Juventus 1–1LecceRegular Season - 18 | D |
| Jan 06 | Serie A | Lecce0–2 AS RomaRegular Season - 19 | L |
| Jan 11 | Serie A | Lecce1–2ParmaRegular Season - 20 | L |
| Jan 14 | Serie A | Inter 1–0LecceRegular Season - 16 | L |
| Jan 18 | Serie A | AC Milan1–0LecceRegular Season - 21 | L |
| Jan 24 | Serie A | Lecce0–0LazioRegular Season - 22 | D |
| February 2026Feb 01 | Serie A | Torino1–0LecceRegular Season - 23 | L |
| Feb 08 | Serie A | Lecce2–1UdineseRegular Season - 24 | W |
| Feb 16 | Serie A | Cagliari0–2LecceRegular Season - 25 | W |
| Feb 21 | Serie A | Lecce0–2InterRegular Season - 26 | L |
| Feb 28 | Serie A | Como3–1LecceRegular Season - 27 | L |
| March 2026Mar 08 | Serie A | Lecce2–1CremoneseRegular Season - 28 | W |
| Mar 14 | Serie A | Napoli2–1LecceRegular Season - 29 | L |
| Mar 22 | Serie A | AS Roma1–0LecceRegular Season - 30 | L |
| April 2026Apr 06 | Serie A | Lecce0–3AtalantaRegular Season - 31 | L |
| Apr 12 | Serie A | Bologna2–0LecceRegular Season - 32 | L |
| Apr 20 | Serie A | Lecce1–1FiorentinaRegular Season - 33 | D |
| Apr 25 | Serie A | Hellas Verona0–0LecceRegular Season - 34 | D |
| May 2026May 01 | Serie A | Pisa1–2LecceRegular Season - 35 | W |
| May 09 | Serie A | Lecce0–1JuventusRegular Season - 36 | L |
| May 17 | Serie A | Sassuolo2–3LecceRegular Season - 37 | W |
| May 24 | Serie A | Lecce1–0GenoaRegular Season - 38 | W |
