| agosto de 202320 ago |  Serie A | Lecce 2–1 LazioRegular Season - 1 | V |
| 27 ago | Serie A | Fiorentina 2–2LecceRegular Season - 2 | E |
| septiembre de 202303 sept | Serie A | Lecce2–0 SalernitanaRegular Season - 3 | V |
| 17 sept | Serie A | Monza 1–1LecceRegular Season - 4 | E |
| 22 sept | Serie A | Lecce1–0 GenoaRegular Season - 5 | V |
| 26 sept | Serie A | Juventus 1–0LecceRegular Season - 6 | D |
| 30 sept | Serie A | Lecce0–4 NapoliRegular Season - 7 | D |
| octubre de 202306 oct | Serie A | Lecce1–1 SassuoloRegular Season - 8 | E |
| 23 oct | Serie A | Udinese 1–1LecceRegular Season - 9 | E |
| 28 oct | Serie A | Lecce0–1 TorinoRegular Season - 10 | D |
| noviembre de 202305 nov | Serie A | AS Roma 2–1LecceRegular Season - 11 | D |
| 11 nov | Serie A | Lecce2–2 AC MilanRegular Season - 12 | E |
| 27 nov | Serie A | Hellas Verona 2–2LecceRegular Season - 13 | E |
| diciembre de 202303 dic | Serie A | Lecce1–1 BolognaRegular Season - 14 | E |
| 11 dic | Serie A | Empoli 1–1LecceRegular Season - 15 | E |
| 16 dic | Serie A | Lecce2–1 FrosinoneRegular Season - 16 | V |
| 23 dic | Serie A | Inter 2–0LecceRegular Season - 17 | D |
| 30 dic | Serie A | Atalanta 1–0LecceRegular Season - 18 | D |
| enero de 202406 ene | Serie A | Lecce1–1 CagliariRegular Season - 19 | E |
| 14 ene | Serie A | Lazio1–0LecceRegular Season - 20 | D |
| 21 ene | Serie A | Lecce0–3JuventusRegular Season - 21 | D |
| 28 ene | Serie A | Genoa2–1LecceRegular Season - 22 | D |
| febrero de 202402 feb | Serie A | Lecce3–2FiorentinaRegular Season - 23 | V |
| 11 feb | Serie A | Bologna4–0LecceRegular Season - 24 | D |
| 16 feb | Serie A | Torino2–0LecceRegular Season - 25 | D |
| 25 feb | Serie A | Lecce0–4InterRegular Season - 26 | D |
| marzo de 202403 mar | Serie A | Frosinone1–1LecceRegular Season - 27 | E |
| 10 mar | Serie A | Lecce0–1Hellas VeronaRegular Season - 28 | D |
| 16 mar | Serie A | Salernitana0–1LecceRegular Season - 29 | V |
| abril de 202401 abr | Serie A | Lecce0–0AS RomaRegular Season - 30 | E |
| 06 abr | Serie A | AC Milan3–0LecceRegular Season - 31 | D |
| 13 abr | Serie A | Lecce1–0EmpoliRegular Season - 32 | V |
| 21 abr | Serie A | Sassuolo0–3LecceRegular Season - 33 | V |
| 27 abr | Serie A | Lecce1–1MonzaRegular Season - 34 | E |
| mayo de 202405 may | Serie A | Cagliari1–1LecceRegular Season - 35 | E |
| 13 may | Serie A | Lecce0–2UdineseRegular Season - 36 | D |
| 18 may | Serie A | Lecce0–2AtalantaRegular Season - 37 | D |
| 26 may | Serie A | Napoli0–0LecceRegular Season - 38 | E |
