| agosto de 202623 ago |  Serie A | Venezia 16:30 LecceRegular Season - 1 | — |
| 31 ago | Serie A | Lecce16:30 AS RomaRegular Season - 2 | — |
| septiembre de 202607 sept | Serie A | Cagliari 16:00LecceRegular Season - 3 | — |
| 13 sept | Serie A | Lecce13:00 MonzaRegular Season - 4 | — |
| 20 sept | Serie A | AC Milan 18:45LecceRegular Season - 5 | — |
| octubre de 202611 oct | Serie A | Lecce16:30 BolognaRegular Season - 6 | — |
| 18 oct | Serie A | Udinese 16:30LecceRegular Season - 7 | — |
| 25 oct | Serie A | Lecce17:30 JuventusRegular Season - 8 | — |
| 28 oct | Serie A | Frosinone 17:30LecceRegular Season - 9 | — |
| noviembre de 202601 nov | Serie A | Lecce17:30 GenoaRegular Season - 10 | — |
| 08 nov | Serie A | Torino 17:30LecceRegular Season - 11 | — |
| 22 nov | Serie A | Lazio 17:30LecceRegular Season - 12 | — |
| 29 nov | Serie A | Lecce17:30 AtalantaRegular Season - 13 | — |
| diciembre de 202606 dic | Serie A | Napoli 17:30LecceRegular Season - 14 | — |
| 13 dic | Serie A | Lecce17:30 SassuoloRegular Season - 15 | — |
| 20 dic | Serie A | Lecce17:30 InterRegular Season - 16 | — |
| enero de 202703 ene | Serie A | Como 17:30LecceRegular Season - 17 | — |
| 06 ene | Serie A | Lecce17:30 ParmaRegular Season - 18 | — |
| 10 ene | Serie A | Fiorentina 17:30LecceRegular Season - 19 | — |
| 17 ene | Serie A | Lecce17:30UdineseRegular Season - 20 | — |
| 24 ene | Serie A | Lecce17:30TorinoRegular Season - 21 | — |
| 31 ene | Serie A | Genoa17:30LecceRegular Season - 22 | — |
| febrero de 202707 feb | Serie A | Lecce17:30NapoliRegular Season - 23 | — |
| 14 feb | Serie A | Monza17:30LecceRegular Season - 24 | — |
| 21 feb | Serie A | Lecce17:30FrosinoneRegular Season - 25 | — |
| 28 feb | Serie A | Bologna17:30LecceRegular Season - 26 | — |
| marzo de 202707 mar | Serie A | Lecce17:30ComoRegular Season - 27 | — |
| 14 mar | Serie A | Parma17:30LecceRegular Season - 28 | — |
| 21 mar | Serie A | AS Roma17:30LecceRegular Season - 29 | — |
| abril de 202704 abr | Serie A | Lecce16:30LazioRegular Season - 30 | — |
| 11 abr | Serie A | Juventus16:30LecceRegular Season - 31 | — |
| 18 abr | Serie A | Sassuolo16:30LecceRegular Season - 32 | — |
| 25 abr | Serie A | Lecce16:30AC MilanRegular Season - 33 | — |
| mayo de 202702 may | Serie A | Lecce16:30CagliariRegular Season - 34 | — |
| 09 may | Serie A | Inter16:30LecceRegular Season - 35 | — |
| 16 may | Serie A | Lecce16:30FiorentinaRegular Season - 36 | — |
| 23 may | Serie A | Atalanta16:30LecceRegular Season - 37 | — |
| 30 may | Serie A | Lecce16:30VeneziaRegular Season - 38 | — |
