| août 202418 août |  Ligue 1 | Rennes 3–0 LyonRegular Season - 1 | D |
| 24 août | Ligue 1 | Lyon0–2 MonacoRegular Season - 2 | D |
| 30 août | Ligue 1 | Lyon4–3 StrasbourgRegular Season - 3 | V |
| septembre 202415 sept. | Ligue 1 | Lens 0–0LyonRegular Season - 4 | N |
| 22 sept. | Ligue 1 | Lyon2–3 MarseilleRegular Season - 5 | D |
| 26 sept. |  Europa League | Lyon2–0 Olympiakos PiraeusLeague Stage - 1 | V |
| 29 sept. | Ligue 1 | Toulouse 1–2LyonRegular Season - 6 | V |
| octobre 202403 oct. | Europa League | Rangers 1–4LyonLeague Stage - 2 | V |
| 06 oct. | Ligue 1 | Lyon2–0 NantesRegular Season - 7 | V |
| 20 oct. | Ligue 1 | Le Havre 0–4LyonRegular Season - 8 | V |
| 24 oct. | Europa League | Lyon0–1 BeşiktaşLeague Stage - 3 | D |
| 27 oct. | Ligue 1 | Lyon2–2 AuxerreRegular Season - 9 | N |
| novembre 202401 nov. | Ligue 1 | Lille 1–1LyonRegular Season - 10 | N |
| 07 nov. | Europa League | 1899 Hoffenheim 2–2LyonLeague Stage - 4 | N |
| 10 nov. | Ligue 1 | Lyon1–0 Saint EtienneRegular Season - 11 | V |
| 23 nov. | Ligue 1 | Reims 1–1LyonRegular Season - 12 | N |
| 28 nov. | Europa League | Qarabag 1–4LyonLeague Stage - 5 | V |
| décembre 202401 déc. | Ligue 1 | Lyon4–1 NiceRegular Season - 13 | V |
| 07 déc. | Ligue 1 | Angers 0–3LyonRegular Season - 14 | V |
| 12 déc. | Europa League | Lyon3–2 Eintracht FrankfurtLeague Stage - 6 | V |
| 15 déc. | Ligue 1 | Paris Saint Germain 3–1LyonRegular Season - 15 | D |
| janvier 202504 janv. | Ligue 1 | Lyon1–0 MontpellierRegular Season - 16 | V |
| 11 janv. | Ligue 1 | Stade Brestois 29 2–1LyonRegular Season - 17 | D |
| 18 janv. | Ligue 1 | Lyon0–0ToulouseRegular Season - 18 | N |
| 23 janv. | Europa League | Fenerbahçe 0–0LyonLeague Stage - 7 | N |
| 26 janv. | Ligue 1 | Nantes1–1LyonRegular Season - 19 | N |
| 30 janv. | Europa League | Lyon1–1 LudogoretsLeague Stage - 8 | N |
| février 202502 févr. | Ligue 1 | Marseille3–2LyonRegular Season - 20 | D |
| 09 févr. | Ligue 1 | Lyon4–0ReimsRegular Season - 21 | V |
| 16 févr. | Ligue 1 | Montpellier1–4LyonRegular Season - 22 | V |
| 23 févr. | Ligue 1 | Lyon2–3Paris Saint GermainRegular Season - 23 | D |
| mars 202502 mars | Ligue 1 | Lyon2–1Stade Brestois 29Regular Season - 24 | V |
| 06 mars | Europa League | FCSB 1–3LyonRound of 16 | V |
| 09 mars | Ligue 1 | Nice0–2LyonRegular Season - 25 | V |
| 13 mars | Europa League | Lyon4–0FCSBRound of 16 | V |
| 16 mars | Ligue 1 | Lyon4–2Le HavreRegular Season - 26 | V |
| 28 mars | Ligue 1 | Strasbourg4–2LyonRegular Season - 27 | D |
| avril 202505 avr. | Ligue 1 | Lyon2–1LilleRegular Season - 28 | V |
| 10 avr. | Europa League | Lyon2–2 Manchester UnitedQuarter-finals | N |
| 13 avr. | Ligue 1 | Auxerre1–3LyonRegular Season - 29 | V |
| 17 avr. | Europa League | Manchester United5–4LyonQuarter-finals | D |
| 20 avr. | Ligue 1 | Saint Etienne2–1LyonRegular Season - 30 | D |
| 26 avr. | Ligue 1 | Lyon4–1RennesRegular Season - 31 | V |
| mai 202504 mai | Ligue 1 | Lyon1–2LensRegular Season - 32 | D |
| 10 mai | Ligue 1 | Monaco2–0LyonRegular Season - 33 | D |
| 17 mai | Ligue 1 | Lyon2–0AngersRegular Season - 34 | V |
