| août 202516 août |  Ligue 1 | Lens 0–1 LyonRegular Season - 1 | V |
| 23 août | Ligue 1 | Lyon3–0 MetzRegular Season - 2 | V |
| 31 août | Ligue 1 | Lyon1–0 MarseilleRegular Season - 3 | V |
| septembre 202514 sept. | Ligue 1 | Rennes 3–1LyonRegular Season - 4 | D |
| 19 sept. | Ligue 1 | Lyon1–0 AngersRegular Season - 5 | V |
| 25 sept. |  Europa League | Utrecht 0–1LyonLeague Stage - 1 | V |
| 28 sept. | Ligue 1 | Lille 0–1LyonRegular Season - 6 | V |
| octobre 202502 oct. | Europa League | Lyon2–0 Red Bull SalzburgLeague Stage - 2 | V |
| 05 oct. | Ligue 1 | Lyon1–2 ToulouseRegular Season - 7 | D |
| 18 oct. | Ligue 1 | Nice 3–2LyonRegular Season - 8 | D |
| 23 oct. | Europa League | Lyon2–0 FC Basel 1893League Stage - 3 | V |
| 26 oct. | Ligue 1 | Lyon2–1 StrasbourgRegular Season - 9 | V |
| 29 oct. | Ligue 1 | Paris FC 3–3LyonRegular Season - 10 | N |
| novembre 202502 nov. | Ligue 1 | Stade Brestois 29 0–0LyonRegular Season - 11 | N |
| 06 nov. | Europa League | Real Betis 2–0LyonLeague Stage - 4 | D |
| 09 nov. | Ligue 1 | Lyon2–3 Paris Saint GermainRegular Season - 12 | D |
| 23 nov. | Ligue 1 | Auxerre 0–0LyonRegular Season - 13 | N |
| 27 nov. | Europa League | Maccabi Tel Aviv 0–6LyonLeague Stage - 5 | V |
| 30 nov. | Ligue 1 | Lyon3–0 NantesRegular Season - 14 | V |
| décembre 202507 déc. | Ligue 1 | Lorient 1–0LyonRegular Season - 15 | D |
| 11 déc. | Europa League | Lyon2–1 GO Ahead EaglesLeague Stage - 6 | V |
| 14 déc. | Ligue 1 | Lyon1–0 Le HavreRegular Season - 16 | V |
| janvier 202603 janv. | Ligue 1 | Monaco 1–3LyonRegular Season - 17 | V |
| 18 janv. | Ligue 1 | Lyon2–1Stade Brestois 29Regular Season - 18 | V |
| 22 janv. | Europa League | BSC Young Boys 0–1LyonLeague Stage - 7 | V |
| 25 janv. | Ligue 1 | Metz2–5LyonRegular Season - 19 | V |
| 29 janv. | Europa League | Lyon4–2 PAOKLeague Stage - 8 | V |
| février 202601 févr. | Ligue 1 | Lyon1–0LilleRegular Season - 20 | V |
| 07 févr. | Ligue 1 | Nantes0–1LyonRegular Season - 21 | V |
| 15 févr. | Ligue 1 | Lyon2–0NiceRegular Season - 22 | V |
| 22 févr. | Ligue 1 | Strasbourg3–1LyonRegular Season - 23 | D |
| mars 202601 mars | Ligue 1 | Marseille3–2LyonRegular Season - 24 | D |
| 08 mars | Ligue 1 | Lyon1–1Paris FCRegular Season - 25 | N |
| 12 mars | Europa League | Celta Vigo 1–1LyonRound of 16 | N |
| 15 mars | Ligue 1 | Le Havre0–0LyonRegular Season - 26 | N |
| 19 mars | Europa League | Lyon0–2Celta VigoRound of 16 | D |
| 22 mars | Ligue 1 | Lyon1–2MonacoRegular Season - 27 | D |
| avril 202605 avr. | Ligue 1 | Angers0–0LyonRegular Season - 28 | N |
| 12 avr. | Ligue 1 | Lyon2–0LorientRegular Season - 29 | V |
| 19 avr. | Ligue 1 | Paris Saint Germain1–2LyonRegular Season - 30 | V |
| 25 avr. | Ligue 1 | Lyon3–2AuxerreRegular Season - 31 | V |
| mai 202603 mai | Ligue 1 | Lyon4–2RennesRegular Season - 32 | V |
| 10 mai | Ligue 1 | Toulouse2–1LyonRegular Season - 33 | D |
| 17 mai | Ligue 1 | Lyon0–4LensRegular Season - 34 | D |
