| August 2025Aug 24 |  Serie A | Cagliari 1–1 FiorentinaRegular Season - 1 | D |
| Aug 30 | Serie A | Napoli 1–0CagliariRegular Season - 2 | L |
| September 2025Sep 13 | Serie A | Cagliari2–0 ParmaRegular Season - 3 | W |
| Sep 19 | Serie A | Lecce 1–2CagliariRegular Season - 4 | W |
| Sep 27 | Serie A | Cagliari0–2 InterRegular Season - 5 | L |
| October 2025Oct 05 | Serie A | Udinese 1–1CagliariRegular Season - 6 | D |
| Oct 19 | Serie A | Cagliari0–2 BolognaRegular Season - 7 | L |
| Oct 26 | Serie A | Hellas Verona 2–2CagliariRegular Season - 8 | D |
| Oct 30 | Serie A | Cagliari1–2 SassuoloRegular Season - 9 | L |
| November 2025Nov 03 | Serie A | Lazio 2–0CagliariRegular Season - 10 | L |
| Nov 08 | Serie A | Como 0–0CagliariRegular Season - 11 | D |
| Nov 22 | Serie A | Cagliari3–3 GenoaRegular Season - 12 | D |
| Nov 29 | Serie A | Juventus 2–1CagliariRegular Season - 13 | L |
| December 2025Dec 07 | Serie A | Cagliari1–0 AS RomaRegular Season - 14 | W |
| Dec 13 | Serie A | Atalanta 2–1CagliariRegular Season - 15 | L |
| Dec 21 | Serie A | Cagliari2–2 PisaRegular Season - 16 | D |
| Dec 27 | Serie A | Torino 1–2CagliariRegular Season - 17 | W |
| January 2026Jan 02 | Serie A | Cagliari0–1 AC MilanRegular Season - 18 | L |
| Jan 08 | Serie A | Cremonese 2–2CagliariRegular Season - 19 | D |
| Jan 12 | Serie A | Genoa3–0CagliariRegular Season - 20 | L |
| Jan 17 | Serie A | Cagliari1–0JuventusRegular Season - 21 | W |
| Jan 24 | Serie A | Fiorentina1–2CagliariRegular Season - 22 | W |
| Jan 31 | Serie A | Cagliari4–0Hellas VeronaRegular Season - 23 | W |
| February 2026Feb 09 | Serie A | AS Roma2–0CagliariRegular Season - 24 | L |
| Feb 16 | Serie A | Cagliari0–2LecceRegular Season - 25 | L |
| Feb 21 | Serie A | Cagliari0–0LazioRegular Season - 26 | D |
| Feb 27 | Serie A | Parma1–1CagliariRegular Season - 27 | D |
| March 2026Mar 07 | Serie A | Cagliari1–2ComoRegular Season - 28 | L |
| Mar 15 | Serie A | Pisa3–1CagliariRegular Season - 29 | L |
| Mar 20 | Serie A | Cagliari0–1NapoliRegular Season - 30 | L |
| April 2026Apr 04 | Serie A | Sassuolo2–1CagliariRegular Season - 31 | L |
| Apr 11 | Serie A | Cagliari1–0CremoneseRegular Season - 32 | W |
| Apr 17 | Serie A | Inter3–0CagliariRegular Season - 33 | L |
| Apr 27 | Serie A | Cagliari3–2AtalantaRegular Season - 34 | W |
| May 2026May 03 | Serie A | Bologna0–0CagliariRegular Season - 35 | D |
| May 09 | Serie A | Cagliari0–2UdineseRegular Season - 36 | L |
| May 17 | Serie A | Cagliari2–1TorinoRegular Season - 37 | W |
| May 24 | Serie A | AC Milan1–2CagliariRegular Season - 38 | W |
