| February 2021Feb 16 |  Liga Profesional Argentina | Independiente 0–1 Lanus1st Phase - 1 | W |
| Feb 20 | Liga Profesional Argentina | Lanus2–1 Defensa Y Justicia1st Phase - 2 | W |
| March 2021Mar 01 | Liga Profesional Argentina | Union Santa Fe 3–2Lanus1st Phase - 3 | L |
| Mar 06 | Liga Profesional Argentina | Lanus2–1 Atletico Tucuman1st Phase - 4 | W |
| Mar 13 | Liga Profesional Argentina | Huracan 0–0Lanus1st Phase - 5 | D |
| Mar 20 | Liga Profesional Argentina | Banfield 2–0Lanus1st Phase - 6 | L |
| Mar 26 | Liga Profesional Argentina | Lanus4–2 Patronato1st Phase - 7 | W |
| April 2021Apr 03 | Liga Profesional Argentina | Gimnasia L.P. 2–4Lanus1st Phase - 8 | W |
| Apr 14 | Liga Profesional Argentina | Lanus1–3 Newells Old Boys1st Phase - 9 | L |
| Apr 17 | Liga Profesional Argentina | Sarmiento Junin 1–0Lanus1st Phase - 10 | L |
| Apr 25 | Liga Profesional Argentina | Lanus1–2 Velez Sarsfield1st Phase - 11 | L |
| May 2021May 02 | Liga Profesional Argentina | Boca Juniors 1–0Lanus1st Phase - 12 | L |
| May 09 | Liga Profesional Argentina | Lanus1–0 Talleres Cordoba1st Phase - 13 | W |
| July 2021Jul 17 | Liga Profesional Argentina | Lanus4–2Atletico Tucuman2nd Phase - 1 | W |
| Jul 24 | Liga Profesional Argentina | Colon Santa Fe 1–4Lanus2nd Phase - 2 | W |
| Jul 29 | Liga Profesional Argentina | Lanus0–3 River Plate2nd Phase - 3 | L |
| Jul 31 | Liga Profesional Argentina | Lanus1–1Union Santa Fe2nd Phase - 4 | D |
| August 2021Aug 07 | Liga Profesional Argentina | Huracan0–1Lanus2nd Phase - 5 | W |
| Aug 17 | Liga Profesional Argentina | Lanus3–1 Godoy Cruz2nd Phase - 6 | W |
| Aug 21 | Liga Profesional Argentina | Velez Sarsfield5–1Lanus2nd Phase - 7 | L |
| Aug 25 | Liga Profesional Argentina | Lanus2–0Gimnasia L.P.2nd Phase - 8 | W |
| Aug 29 | Liga Profesional Argentina | Aldosivi 2–3Lanus2nd Phase - 9 | W |
| September 2021Sep 04 | Liga Profesional Argentina | Lanus1–1Sarmiento Junin2nd Phase - 10 | D |
| Sep 13 | Liga Profesional Argentina | Independiente0–1Lanus2nd Phase - 11 | W |
| Sep 20 | Liga Profesional Argentina | Lanus1–2Newells Old Boys2nd Phase - 12 | L |
| Sep 25 | Liga Profesional Argentina | Arsenal Sarandi 1–0Lanus2nd Phase - 13 | L |
| October 2021Oct 02 | Liga Profesional Argentina | Lanus2–1 Central Cordoba de Santiago2nd Phase - 14 | W |
| Oct 10 | Liga Profesional Argentina | Boca Juniors4–2Lanus2nd Phase - 15 | L |
| Oct 16 | Liga Profesional Argentina | Lanus1–1Banfield2nd Phase - 16 | D |
| Oct 20 | Liga Profesional Argentina | San Lorenzo 1–3Lanus2nd Phase - 17 | W |
| Oct 25 | Liga Profesional Argentina | Lanus3–3Talleres Cordoba2nd Phase - 18 | D |
| Oct 30 | Liga Profesional Argentina | Argentinos JRS 0–1Lanus2nd Phase - 19 | W |
| November 2021Nov 06 | Liga Profesional Argentina | Lanus1–1 Estudiantes L.P.2nd Phase - 20 | D |
| Nov 18 | Liga Profesional Argentina | Patronato3–2Lanus2nd Phase - 21 | L |
| Nov 25 | Liga Profesional Argentina | Lanus3–3 Platense2nd Phase - 22 | D |
| Nov 29 | Liga Profesional Argentina | Racing Club 3–1Lanus2nd Phase - 23 | L |
| December 2021Dec 05 | Liga Profesional Argentina | Lanus2–2 Rosario Central2nd Phase - 24 | D |
| Dec 12 | Liga Profesional Argentina | Defensa Y Justicia2–1Lanus2nd Phase - 25 | L |
