| August 2022Aug 05 |  Coppa Italia | Lecce 2–3 Cittadella1st Round | L |
| Aug 13 |  Serie A | Lecce1–2 InterRegular Season - 1 | L |
| Aug 20 | Serie A | Sassuolo 1–0LecceRegular Season - 2 | L |
| Aug 28 | Serie A | Lecce1–1 EmpoliRegular Season - 3 | D |
| Aug 31 | Serie A | Napoli 1–1LecceRegular Season - 4 | D |
| September 2022Sep 05 | Serie A | Torino 1–0LecceRegular Season - 5 | L |
| Sep 11 | Serie A | Lecce1–1 MonzaRegular Season - 6 | D |
| Sep 16 | Serie A | Salernitana 1–2LecceRegular Season - 7 | W |
| October 2022Oct 02 | Serie A | Lecce1–1 CremoneseRegular Season - 8 | D |
| Oct 09 | Serie A | AS Roma 2–1LecceRegular Season - 9 | L |
| Oct 17 | Serie A | Lecce1–1 FiorentinaRegular Season - 10 | D |
| Oct 23 | Serie A | Bologna 2–0LecceRegular Season - 11 | L |
| Oct 29 | Serie A | Lecce0–1 JuventusRegular Season - 12 | L |
| November 2022Nov 04 | Serie A | Udinese 1–1LecceRegular Season - 13 | D |
| Nov 09 | Serie A | Lecce2–1 AtalantaRegular Season - 14 | W |
| Nov 12 | Serie A | Sampdoria 0–2LecceRegular Season - 15 | W |
| January 2023Jan 04 | Serie A | Lecce2–1 LazioRegular Season - 16 | W |
| Jan 08 | Serie A | Spezia 0–0LecceRegular Season - 17 | D |
| Jan 14 | Serie A | Lecce2–2 AC MilanRegular Season - 18 | D |
| Jan 21 | Serie A | Hellas Verona 2–0LecceRegular Season - 19 | L |
| Jan 27 | Serie A | Lecce1–2SalernitanaRegular Season - 20 | L |
| February 2023Feb 04 | Serie A | Cremonese0–2LecceRegular Season - 21 | W |
| Feb 11 | Serie A | Lecce1–1AS RomaRegular Season - 22 | D |
| Feb 19 | Serie A | Atalanta1–2LecceRegular Season - 23 | W |
| Feb 25 | Serie A | Lecce0–1SassuoloRegular Season - 24 | L |
| March 2023Mar 05 | Serie A | Inter2–0LecceRegular Season - 25 | L |
| Mar 12 | Serie A | Lecce0–2TorinoRegular Season - 26 | L |
| Mar 19 | Serie A | Fiorentina1–0LecceRegular Season - 27 | L |
| April 2023Apr 03 | Serie A | Empoli1–0LecceRegular Season - 28 | L |
| Apr 07 | Serie A | Lecce1–2NapoliRegular Season - 29 | L |
| Apr 16 | Serie A | Lecce1–1SampdoriaRegular Season - 30 | D |
| Apr 23 | Serie A | AC Milan2–0LecceRegular Season - 31 | L |
| Apr 28 | Serie A | Lecce1–0UdineseRegular Season - 32 | W |
| May 2023May 03 | Serie A | Juventus2–1LecceRegular Season - 33 | L |
| May 07 | Serie A | Lecce0–1Hellas VeronaRegular Season - 34 | L |
| May 12 | Serie A | Lazio2–2LecceRegular Season - 35 | D |
| May 21 | Serie A | Lecce0–0SpeziaRegular Season - 36 | D |
| May 28 | Serie A | Monza0–1LecceRegular Season - 37 | W |
| June 2023Jun 04 | Serie A | Lecce2–3BolognaRegular Season - 38 | L |
