| August 2022Aug 07 |  Ligue 1 | Rennes 0–1 LorientRegular Season - 1 | L |
| Aug 13 | Ligue 1 | Monaco 1–1RennesRegular Season - 2 | D |
| Aug 21 | Ligue 1 | Rennes2–1 AjaccioRegular Season - 3 | W |
| Aug 27 | Ligue 1 | Lens 2–1RennesRegular Season - 4 | L |
| Aug 31 | Ligue 1 | Rennes3–1 Stade Brestois 29Regular Season - 5 | W |
| September 2022Sep 04 | Ligue 1 | Estac Troyes 1–1RennesRegular Season - 6 | D |
| Sep 08 |  Europa League | AEK Larnaca 1–2RennesGroup Stage - 1 | W |
| Sep 11 | Ligue 1 | Rennes5–0 AuxerreRegular Season - 7 | W |
| Sep 15 | Europa League | Rennes2–2 FenerbahçeGroup Stage - 2 | D |
| Sep 18 | Ligue 1 | Marseille 1–1RennesRegular Season - 8 | D |
| October 2022Oct 01 | Ligue 1 | Strasbourg 1–3RennesRegular Season - 9 | W |
| Oct 06 | Europa League | Rennes2–1 Dynamo KyivGroup Stage - 3 | W |
| Oct 09 | Ligue 1 | Rennes3–0 NantesRegular Season - 10 | W |
| Oct 13 | Europa League | Dynamo Kyiv0–1RennesGroup Stage - 4 | W |
| Oct 16 | Ligue 1 | Rennes3–2 LyonRegular Season - 11 | W |
| Oct 23 | Ligue 1 | Angers 1–2RennesRegular Season - 12 | W |
| Oct 27 | Europa League | Fenerbahçe3–3RennesGroup Stage - 5 | D |
| Oct 30 | Ligue 1 | Rennes3–0 MontpellierRegular Season - 13 | W |
| November 2022Nov 03 | Europa League | Rennes1–1AEK LarnacaGroup Stage - 6 | D |
| Nov 06 | Ligue 1 | Lille 1–1RennesRegular Season - 14 | D |
| Nov 12 | Ligue 1 | Rennes2–1 ToulouseRegular Season - 15 | W |
| December 2022Dec 29 | Ligue 1 | Reims 3–1RennesRegular Season - 16 | L |
| January 2023Jan 02 | Ligue 1 | Rennes2–1 NiceRegular Season - 17 | W |
| Jan 07 |  Coupe de France | Bordeaux 1–2RennesRound of 64 | W |
| Jan 11 | Ligue 1 | Clermont Foot 2–1RennesRegular Season - 18 | L |
| Jan 15 | Ligue 1 | Rennes1–0 Paris Saint GermainRegular Season - 19 | W |
| Jan 20 | Coupe de France | Marseille1–0RennesRound of 32 | L |
| Jan 27 | Ligue 1 | Lorient2–1RennesRegular Season - 20 | L |
| February 2023Feb 01 | Ligue 1 | Rennes3–0StrasbourgRegular Season - 21 | W |
| Feb 04 | Ligue 1 | Rennes1–3LilleRegular Season - 22 | L |
| Feb 12 | Ligue 1 | Toulouse3–1RennesRegular Season - 23 | L |
| Feb 16 | Europa League | Shakhtar Donetsk 2–1RennesKnockout Round Play-offs | L |
| Feb 19 | Ligue 1 | Rennes2–0Clermont FootRegular Season - 24 | W |
| Feb 23 | Europa League | Rennes2–1Shakhtar DonetskKnockout Round Play-offs | W |
| Feb 26 | Ligue 1 | Nantes0–1RennesRegular Season - 25 | W |
| March 2023Mar 05 | Ligue 1 | Rennes0–1MarseilleRegular Season - 26 | L |
| Mar 11 | Ligue 1 | Auxerre0–0RennesRegular Season - 27 | D |
| Mar 19 | Ligue 1 | Paris Saint Germain0–2RennesRegular Season - 28 | W |
| April 2023Apr 01 | Ligue 1 | Rennes0–1LensRegular Season - 29 | L |
| Apr 09 | Ligue 1 | Lyon3–1RennesRegular Season - 30 | L |
| Apr 15 | Ligue 1 | Rennes3–0ReimsRegular Season - 31 | W |
| Apr 23 | Ligue 1 | Montpellier1–0RennesRegular Season - 32 | L |
| Apr 30 | Ligue 1 | Rennes4–2AngersRegular Season - 33 | W |
| May 2023May 06 | Ligue 1 | Nice2–1RennesRegular Season - 34 | L |
| May 14 | Ligue 1 | Rennes4–0Estac TroyesRegular Season - 35 | W |
| May 21 | Ligue 1 | Ajaccio0–5RennesRegular Season - 36 | W |
| May 27 | Ligue 1 | Rennes2–0MonacoRegular Season - 37 | W |
| June 2023Jun 03 | Ligue 1 | Stade Brestois 291–2RennesRegular Season - 38 | W |
