| August 2016Aug 21 |  Serie A | Chievo 2–0 InterRegular Season - 1 | L |
| Aug 28 | Serie A | Inter1–1 PalermoRegular Season - 2 | D |
| September 2016Sep 11 | Serie A | Pescara 1–2InterRegular Season - 3 | W |
| Sep 15 |  Europa League | Inter0–2 Hapoel Beer ShevaGroup Stage - 1 | L |
| Sep 18 | Serie A | Inter2–1 JuventusRegular Season - 4 | W |
| Sep 21 | Serie A | Empoli 0–2InterRegular Season - 5 | W |
| Sep 25 | Serie A | Inter1–1 BolognaRegular Season - 6 | D |
| Sep 29 | Europa League | Sparta Praha 3–1InterGroup Stage - 2 | L |
| October 2016Oct 02 | Serie A | AS Roma 2–1InterRegular Season - 7 | L |
| Oct 16 | Serie A | Inter1–2 CagliariRegular Season - 8 | L |
| Oct 20 | Europa League | Inter1–0 SouthamptonGroup Stage - 3 | W |
| Oct 23 | Serie A | Atalanta 2–1InterRegular Season - 9 | L |
| Oct 26 | Serie A | Inter2–1 TorinoRegular Season - 10 | W |
| Oct 30 | Serie A | Sampdoria 1–0InterRegular Season - 11 | L |
| November 2016Nov 03 | Europa League | Southampton2–1InterGroup Stage - 4 | L |
| Nov 06 | Serie A | Inter3–0 CrotoneRegular Season - 12 | W |
| Nov 20 | Serie A | AC Milan 2–2InterRegular Season - 13 | D |
| Nov 24 | Europa League | Hapoel Beer Sheva3–2InterGroup Stage - 5 | L |
| Nov 28 | Serie A | Inter4–2 FiorentinaRegular Season - 14 | W |
| December 2016Dec 02 | Serie A | Napoli 3–0InterRegular Season - 15 | L |
| Dec 08 | Europa League | Inter2–1Sparta PrahaGroup Stage - 6 | W |
| Dec 11 | Serie A | Inter2–0 GenoaRegular Season - 16 | W |
| Dec 18 | Serie A | Sassuolo 0–1InterRegular Season - 17 | W |
| Dec 21 | Serie A | Inter3–0 LazioRegular Season - 18 | W |
| January 2017Jan 08 | Serie A | Udinese 1–2InterRegular Season - 19 | W |
| Jan 14 | Serie A | Inter3–1ChievoRegular Season - 20 | W |
| Jan 22 | Serie A | Palermo0–1InterRegular Season - 21 | W |
| Jan 28 | Serie A | Inter3–0PescaraRegular Season - 22 | W |
| February 2017Feb 05 | Serie A | Juventus1–0InterRegular Season - 23 | L |
| Feb 12 | Serie A | Inter2–0EmpoliRegular Season - 24 | W |
| Feb 19 | Serie A | Bologna0–1InterRegular Season - 25 | W |
| Feb 26 | Serie A | Inter1–3AS RomaRegular Season - 26 | L |
| March 2017Mar 05 | Serie A | Cagliari1–5InterRegular Season - 27 | W |
| Mar 12 | Serie A | Inter7–1AtalantaRegular Season - 28 | W |
| Mar 18 | Serie A | Torino2–2InterRegular Season - 29 | D |
| April 2017Apr 03 | Serie A | Inter1–2SampdoriaRegular Season - 30 | L |
| Apr 09 | Serie A | Crotone2–1InterRegular Season - 31 | L |
| Apr 15 | Serie A | Inter2–2AC MilanRegular Season - 32 | D |
| Apr 22 | Serie A | Fiorentina5–4InterRegular Season - 33 | L |
| Apr 30 | Serie A | Inter0–1NapoliRegular Season - 34 | L |
| May 2017May 07 | Serie A | Genoa1–0InterRegular Season - 35 | L |
| May 14 | Serie A | Inter1–2SassuoloRegular Season - 36 | L |
| May 21 | Serie A | Lazio1–3InterRegular Season - 37 | W |
| May 28 | Serie A | Inter5–2UdineseRegular Season - 38 | W |
