| September 2020Sep 26 |  Serie A | Inter 4–3 FiorentinaRegular Season - 2 | W |
| Sep 30 | Serie A | Benevento 2–5InterRegular Season - 1 | W |
| October 2020Oct 04 | Serie A | Lazio 1–1InterRegular Season - 3 | D |
| Oct 17 | Serie A | Inter1–2 AC MilanRegular Season - 4 | L |
| Oct 21 |  Champions League | Inter2–2 Borussia MönchengladbachGroup B - 1 | D |
| Oct 24 | Serie A | Genoa 0–2InterRegular Season - 5 | W |
| Oct 27 | Champions League | Shakhtar Donetsk 0–0InterGroup B - 2 | D |
| Oct 31 | Serie A | Inter2–2 ParmaRegular Season - 6 | D |
| November 2020Nov 03 | Champions League | Real Madrid 3–2InterGroup B - 3 | L |
| Nov 08 | Serie A | Atalanta 1–1InterRegular Season - 7 | D |
| Nov 22 | Serie A | Inter4–2 TorinoRegular Season - 8 | W |
| Nov 25 | Champions League | Inter0–2Real MadridGroup B - 4 | L |
| Nov 28 | Serie A | Sassuolo 0–3InterRegular Season - 9 | W |
| December 2020Dec 01 | Champions League | Borussia Mönchengladbach2–3InterGroup B - 5 | W |
| Dec 05 | Serie A | Inter3–1 BolognaRegular Season - 10 | W |
| Dec 09 | Champions League | Inter0–0Shakhtar DonetskGroup B - 6 | D |
| Dec 13 | Serie A | Cagliari 1–3InterRegular Season - 11 | W |
| Dec 16 | Serie A | Inter1–0 NapoliRegular Season - 12 | W |
| Dec 20 | Serie A | Inter2–1 SpeziaRegular Season - 13 | W |
| Dec 23 | Serie A | Hellas Verona 1–2InterRegular Season - 14 | W |
| January 2021Jan 03 | Serie A | Inter6–2 CrotoneRegular Season - 15 | W |
| Jan 06 | Serie A | Sampdoria 2–1InterRegular Season - 16 | L |
| Jan 10 | Serie A | AS Roma 2–2InterRegular Season - 17 | D |
| Jan 17 | Serie A | Inter2–0 JuventusRegular Season - 18 | W |
| Jan 23 | Serie A | Udinese 0–0InterRegular Season - 19 | D |
| Jan 30 | Serie A | Inter4–0BeneventoRegular Season - 20 | W |
| February 2021Feb 05 | Serie A | Fiorentina0–2InterRegular Season - 21 | W |
| Feb 14 | Serie A | Inter3–1LazioRegular Season - 22 | W |
| Feb 21 | Serie A | AC Milan0–3InterRegular Season - 23 | W |
| Feb 28 | Serie A | Inter3–0GenoaRegular Season - 24 | W |
| March 2021Mar 04 | Serie A | Parma1–2InterRegular Season - 25 | W |
| Mar 08 | Serie A | Inter1–0AtalantaRegular Season - 26 | W |
| Mar 14 | Serie A | Torino1–2InterRegular Season - 27 | W |
| April 2021Apr 03 | Serie A | Bologna0–1InterRegular Season - 29 | W |
| Apr 07 | Serie A | Inter2–1SassuoloRegular Season - 28 | W |
| Apr 11 | Serie A | Inter1–0CagliariRegular Season - 30 | W |
| Apr 18 | Serie A | Napoli1–1InterRegular Season - 31 | D |
| Apr 21 | Serie A | Spezia1–1InterRegular Season - 32 | D |
| Apr 25 | Serie A | Inter1–0Hellas VeronaRegular Season - 33 | W |
| May 2021May 01 | Serie A | Crotone0–2InterRegular Season - 34 | W |
| May 08 | Serie A | Inter5–1SampdoriaRegular Season - 35 | W |
| May 12 | Serie A | Inter3–1AS RomaRegular Season - 36 | W |
| May 15 | Serie A | Juventus3–2InterRegular Season - 37 | L |
| May 23 | Serie A | Inter5–1UdineseRegular Season - 38 | W |
