| August 2018Aug 19 |  Serie A | Sassuolo 1–0 InterRegular Season - 1 | L |
| Aug 26 | Serie A | Inter2–2 TorinoRegular Season - 2 | D |
| September 2018Sep 01 | Serie A | Bologna 0–3InterRegular Season - 3 | W |
| Sep 15 | Serie A | Inter0–1 ParmaRegular Season - 4 | L |
| Sep 18 |  Champions League | Inter2–1 TottenhamGroup Stage - 1 | W |
| Sep 22 | Serie A | Sampdoria 0–1InterRegular Season - 5 | W |
| Sep 25 | Serie A | Inter2–1 FiorentinaRegular Season - 6 | W |
| Sep 29 | Serie A | Inter2–0 CagliariRegular Season - 7 | W |
| October 2018Oct 03 | Champions League | PSV Eindhoven 1–2InterGroup Stage - 2 | W |
| Oct 07 | Serie A | Spal 1–2InterRegular Season - 8 | W |
| Oct 21 | Serie A | Inter1–0 AC MilanRegular Season - 9 | W |
| Oct 24 | Champions League | Barcelona 2–0InterGroup Stage - 3 | L |
| Oct 29 | Serie A | Lazio 0–3InterRegular Season - 10 | W |
| November 2018Nov 03 | Serie A | Inter5–0 GenoaRegular Season - 11 | W |
| Nov 06 | Champions League | Inter1–1BarcelonaGroup Stage - 4 | D |
| Nov 11 | Serie A | Atalanta 4–1InterRegular Season - 12 | L |
| Nov 24 | Serie A | Inter3–0 FrosinoneRegular Season - 13 | W |
| Nov 28 | Champions League | Tottenham1–0InterGroup Stage - 5 | L |
| December 2018Dec 02 | Serie A | AS Roma 2–2InterRegular Season - 14 | D |
| Dec 07 | Serie A | Juventus 1–0InterRegular Season - 15 | L |
| Dec 11 | Champions League | Inter1–1PSV EindhovenGroup Stage - 6 | D |
| Dec 15 | Serie A | Inter1–0 UdineseRegular Season - 16 | W |
| Dec 22 | Serie A | Chievo 1–1InterRegular Season - 17 | D |
| Dec 26 | Serie A | Inter1–0 NapoliRegular Season - 18 | W |
| Dec 29 | Serie A | Empoli 0–1InterRegular Season - 19 | W |
| January 2019Jan 19 | Serie A | Inter0–0SassuoloRegular Season - 20 | D |
| Jan 27 | Serie A | Torino1–0InterRegular Season - 21 | L |
| February 2019Feb 03 | Serie A | Inter0–1BolognaRegular Season - 22 | L |
| Feb 09 | Serie A | Parma0–1InterRegular Season - 23 | W |
| Feb 14 |  Europa League | Rapid Vienna 0–1Inter16th Finals | W |
| Feb 17 | Serie A | Inter2–1SampdoriaRegular Season - 24 | W |
| Feb 21 | Europa League | Inter4–0Rapid Vienna16th Finals | W |
| Feb 24 | Serie A | Fiorentina3–3InterRegular Season - 25 | D |
| March 2019Mar 01 | Serie A | Cagliari2–1InterRegular Season - 26 | L |
| Mar 07 | Europa League | Eintracht Frankfurt 0–0Inter8th Finals | D |
| Mar 10 | Serie A | Inter2–0SpalRegular Season - 27 | W |
| Mar 14 | Europa League | Inter0–1Eintracht Frankfurt8th Finals | L |
| Mar 17 | Serie A | AC Milan2–3InterRegular Season - 28 | W |
| Mar 31 | Serie A | Inter0–1LazioRegular Season - 29 | L |
| April 2019Apr 03 | Serie A | Genoa0–4InterRegular Season - 30 | W |
| Apr 07 | Serie A | Inter0–0AtalantaRegular Season - 31 | D |
| Apr 14 | Serie A | Frosinone1–3InterRegular Season - 32 | W |
| Apr 20 | Serie A | Inter1–1AS RomaRegular Season - 33 | D |
| Apr 27 | Serie A | Inter1–1JuventusRegular Season - 34 | D |
| May 2019May 04 | Serie A | Udinese0–0InterRegular Season - 35 | D |
| May 13 | Serie A | Inter2–0ChievoRegular Season - 36 | W |
| May 19 | Serie A | Napoli4–1InterRegular Season - 37 | L |
| May 26 | Serie A | Inter2–1EmpoliRegular Season - 38 | W |
